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KMID : 1134820150440050657
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Journal of the Korean Society of Food Science and Nutrition
2015 Volume.44 No. 5 p.657 ~ p.663
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Radioprotective Effects of Post-Treatment with Hesperetin against γ-Irradiation- Induced Tissue Damage and Oxidative Stress in BALB/c Mice
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Kang Jung-Ae
Nam You-Ree
Rho Jong-Kook
Jang Beom-Su
Chung Young-Jin
Park Sang-Hyun
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Abstract
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Ionizing radiation induces cell damage through formation of reactive oxygen species. The present study was designed to evaluate the protective effects of post-treatment with hesperetin against γ-irradiation-induced cellular damage and oxidative stress in BALB/c mice. Healthy female BALB/c mice were exposed to γ-irradiation and administered hesperetin (25 mg/kg and 50 mg/kg, b.w., orally) for 7 days after 6 Gy of γ-irradiation. Exposure to γ-irradiation resulted in hematopoietic system damage manifested as decreases in spleen indexes and WBC count. In addition, hepatocellular damage characterized by increased levels of aspartate aminoransferase (AST) and alanine aminotransferase (ALT) in plasma. However, post-irradiation treatment with hesperetin provided significant protection against hematopoietic system damage and decreased AST and ALT levels in plasma. The results indicate that γ-irradiation induced increases in lipid peroxidation and xanthine oxidase (XO) as well as decreases in antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione (GSH) in the liver. These effects were also attenuated by post-treatment with hesperetin, which decreased lipid peroxidation and XO as well as increased antioxidant enzymes and GSH. These results show that post-treatment with hesperetin offers protection against γ-irradiation-induced tissue damage and oxidative stress and can be developed as an effective radioprotector during radiotherapy.
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KEYWORD
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hesperetin, γ-irradiation, tissue damage, oxidative stress
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